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Feeling flat, foggy, or unlike yourself is not a personality flaw. It can be a hormone story hiding in plain sight. We sit down with Dr Zak Zafrani, a GP with a specialist focus on men’s health, to unpack why testosterone deficiency is often missed, how stigma keeps men quiet, and what a safe, evidence-based path forward looks like when symptoms start to stack up.
We start with the realities of primary care: short appointments, rigid lab cut-offs, and the quiet discomfort men feel discussing libido, erectile changes, and loss of morning erections. Zak shares audit insights showing how many cases slip through the net, then connects the dots to metabolic health. If you or someone you love lives with prediabetes or type 2 diabetes, this conversation explains the strong link with low testosterone, why screening matters, and how targeted treatment can improve both energy and glycaemic control. We also call out the influencer myth that “more testosterone is better,” breaking down receptor sensitivity, real risks like thickened blood, and the hidden damage caused by black-market compounds.
Before talking prescriptions, we go deep on what actually moves the needle: resistance training two to three times per week, protein-forward, whole-food nutrition, and sleep that restores a healthy morning testosterone rise. We map stress mechanisms—cortisol spikes, anxious arousal, and screens late at night—that quietly blunt hormonal balance, and touch on environmental factors such as microplastics. When true deficiency persists, Zak outlines a responsible TRT approach: careful diagnosis with repeated morning labs, shared decision-making, dosing tailored to response, and ongoing monitoring that safeguards fertility and cardiovascular health.
For clinicians, Zak offers a practical route to upskill—lean on society guidelines, recognise red flags in diabetic and suddenly low-mood patients, and seek mentorship to navigate the nuances between endocrinology and primary care. We end by looking ahead to tech that can help, from continuous glucose monitors to AI-driven insights, and a special focus on athletes and retired athletes who face unique risks after concussions or loss of training structure.
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👤 Guest Biography

Dr Zak Zafrani is a UK-based GP with a specialist focus on men’s health, testosterone deficiency, and sports medicine. A 2025 Androgen Society Emerging Scholar Award recipient, Zak is passionate about closing the gap in hormonal health care for men through evidence-based treatment and a holistic approach that prioritizes lifestyle, sleep, and nutrition. He works both within the NHS and private sector, advocating for safer alternatives to black market TRT and better screening in general practice.

Social Handles:

• LinkedIn: https://www.linkedin.com/in/dr-zak-zafrani/