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Engineered For Endurance Podcasts

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Welcome to the Mountain Dude Podcast, brought to you by Initial Ascent – where we share stories of grit, determination, and the relentless pursuit of growth. This is a space where backcountry hunting meets the deeper lessons of life – success born from struggle, and the art of carrying heavy loads more comfortably, both physically and metaphorically, through faith and perseverance.
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A Magic: the Gathering podcast for the spike rogue. Each week, we brew new decks in Modern and Pioneer. We put our creations to the test and share our findings on the air: what worked, what didn’t, and what can be improved for next time. Are you sick of going 0-5? We can help you go 3-2, in style! Created by Dan Schriever (@CavedanMTG), David Robertson (resident brew master), and Damon Alexander (brewer emeritus), and featuring Zach Ryl (@Manacymbal) & Emi Sagasti (@MordeToLight). Whether yo ...
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Welcome to the White Knuckle Racing Club Podcast And you guessed it. This is all about the world of motorsport and not just cars, but mostly motorsport and anything I want. We might throw in some cooking channel advice at some point and possibly a tutorial on how to perform a frontal Lobotomy. These are the stories of the team principals…engineers…drivers…cooks and cleaners and everyone that's involved in the kindred traveller circus in the world of motorsport. Sit back and enjoy...or stand. ...
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One of the most remarkable feats of biological ‘wizardry’ in the animal kingdom is the ability of some cephalopods (octopuses, squids, and cuttlefish) to rapidly change the color, patterning, and texture of their skin so as to blend in with their background. They accomplish these feats through the linking of neural circuits in the visual system and…
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Got questions? Send us a text! In this episode, we sit down with legendary hunting guide Dan Whitmus, a man who’s lived over 30 years in the wilderness guiding hunters through Alaska, Africa, New Zealand, and the American West. Dan shares jaw-dropping stories, including surviving a self-inflicted knife wound deep in the bush, 300+ pound solo packou…
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During vigorous exercise lactic acid (lactate) levels increase in the blood and during fasting and extended exercise the levels of the ketone BHB (b-hydroxybutyrate) increase. In this episode I talk with Stanford University professor Jonathan Long about his recent discovery that lactate and BHB in the blood are bound to the amino acid phenylalanine…
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Got questions? Send us a text! Justin and Kate Small, two of the best predator hunters on the planet, share their expertise on wolf hunting tactics that can make you a more effective hunter. • Kate's background includes nursing in Tanzania where she spent four months providing healthcare in poverty-stricken areas, including two months living with t…
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White matter consists of bundles of long axons that convey information between neural circuits between different brain regions within and between brain hemispheres. These long axons are wrapped with many layers of lipid-rich membranes of oligodendrocytes (a type of glial cell) and it is this ‘insulation’ that enables rapid propagation of signals ov…
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Got questions? Send us a text! In this episode, our host Chris Young shares the full story of his 2025 Idaho spring bear hunt. From rivers crossed with pack rafts to glassing for days in high mountain wind, this conversation captures the highs, lows, and lessons of a truly special backcountry experience. Along the way, Chris reflects on the power o…
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Got questions? Send us a text! In this episode of the Mountain Dude Podcast, filmmaker and backcountry hunter Martin Chagnovich shares the story behind his film Chasing 200, which documents his years-long pursuit of a 200-inch mule deer buck in the rugged Utah mountains. The conversation explores Martin’s roots in hunting, growing up in a hunting f…
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Michael Kreutz is Head of the Neuroplasticity Research Group at the Leibniz Institute for Neurobiology in Magdeburg Germany. Using powerful high resolution microscopy and molecular biology tools his laboratory has shown that autophagy occurs within synapses. Synaptic autophagy is stimulated by neural network activity and is critical for their maint…
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Got questions? Send us a text! In this kickoff episode, host Chris Young along with the Initial Ascent owners Joe Elliston and Dennis Stokes gather around the table to set the stage for something bigger than gear talk or hunting stories (though you’ll get plenty of both). This podcast is about diving deep into faith, failure, triumph, and the relen…
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Belief in supernatural agents and other religious myths arose as a means of ‘explaining’ the unknown and as a tool for social cohesion and hierarchical control of civilizations. Their religiosity is major feature of a ‘believers’ self identity as well as their group identity. Compelling evidence from multiple types of studies have revealed the neur…
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Neurological disorders involve aberrant neural network activity. New technologies are needed for establishing at a fine spatial and temporal resolution the nature of the altered network activity – and for restoring activity to or towards a healthy state. Professor Sri Sarma is an electrical engineer and neuroscientist who is at the forefront of thi…
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Compelling evidence shows that consumption of high fructose corn syrup in soft drinks and ultraprocessed foods has contributed to the increases in obesity, diabetes, fatty liver disease, and dementia that has occurred during the past 50 years. Professor Richard Johnson’s research has been at the forefront of establishing how fructose adversely affe…
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Major progress has recently been made in understanding the aging process at the molecular, cellular, and organ system levels. This knowledge is now being applied in preventative and interventional health care. Moreover, because of the severe burden of age-related diseases on societies governments are increasingly developing strategies to extend hea…
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Remarkable progress has been made towards understanding of the molecular control of neurotransmitter release from presynaptic axon terminals and the responses of the postsynaptic neuron by neurotransmitters. We know that synaptic activity is required for learning and memory but the structural basis of a memory (an engram) remains unknown. Anton Max…
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The outer membrane of cells is comprised of a lipid bilayer consisting of phospholipids, cholesterol, arachidonic acid, omega-3 fatty acids, and others. Embedded in the membrane are various proteins that play roles critical to the survival and function of the cell. Examples of membrane proteins of particular importance for neurons are: ion channels…
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A fascinating feature of interactions between two people is that neural network activity patterns in their brain can become synchronized. In this episode Francesco Papaleo talks about research studies in which activities of neuronal networks are recorded simultaneously in interacting humans or mice. His work has recently focused on the role of inte…
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Neural networks in the brain are active 24/7 and so require a continuous supply of nutrients via the cerebral blood vessels. As we age the cerebral vascular system can become compromised resulting in damage to neurons and a consequent impairment of cognition. Cerebrovascular dementia is a major cause of morbidity and mortality in the elderly but ca…
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William Brady deploys behavioral experiments, big data analytics, and natural language processing to elucidate how human psychology interacts with social media technology to affect morality, emotions, and decision-making. Until very recently in their evolution any one human interacted with no more than a few dozen others during their lifetime. More…
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Season 24, Episode 05: Brewer's Guide to Tarkir (Full Set Review, Part 2) Zach "Manacymbal" Ryl returns for the second half of our brewer's guide to Tarkir Dragonstorm in Pioneer and Modern. Three hours of mayhem ensue. There's tons to explore in this gorgeous new set, but do any of these sweet widdle dragons have what it takes to overthrow the iro…
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In this episode I provide an overview of the evidence that certain chemicals produced by plants and fungi are beneficial for brain function and health. I focus on the fact that the function of these phytochemicals or mycochemicals in the plants or mushrooms is to defend them from being consumed by insects and other animals. We and other animals evo…
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The vast majority of research on the cellular and molecular mechanisms of the storage and retrieval of memories has focused on the excitatory glutamatergic neurons that convey signals into and throughout the brain. However, recent research has revealed the importance of widespread oscillations in neural network activity (particularly gamma and thet…
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Research has shown that excessive dietary protein intake and high amounts of branch-chain amino acids (BCAA) in particular can accelerate aging and exacerbate chronic diseases of aging. In this episode University of Wisconsin Assoc. Professor Dudley Lamming talks about the cellular amino acid sensing mTOR pathway and its influences on aging and dis…
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Dopamine is best known as a neurotransmitter involved in the experiencing of pleasure and reward, and for its role in addiction to drugs, gambling, food, etc. But dopamine is also very important in the brain’s ability to evaluate computational tradeoffs (cost versus benefit) and make decisions. In this episode Roshan Cools a Professor of cognitive …
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In this episode I talk with Professor Maryanne Garry at the University of Waikato New Zealand about several interrelated realms of human cognition that are fundamental to changes in the behaviors of individuals and social groups as influenced by electronic media and artificial intelligence. Dr. Garry has devoted her career to understanding how memo…
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It had long been thought that the brain was ‘immunologically privileged’ (physically separated from the immune system). However, this dogma was overturned by a series of discoveries including those made by Professor Michal Schwartz at the Weizmann Institute. In this episode I talk with Michal about the different types of immune cells that are locat…
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Throughout our waking hours neural networks in our brains are processing incoming information, particularly sights and sounds, integrating those inputs with stored information, making decisions, and executing responses. Staying on task requires that we attend to the details of the task while filtering out ‘noise’. In this episode I talk with Diego …
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Professor Thomas Hartung has made a major impact in biomedical research by developing and promoting alternatives to animal research. His efforts are leading to more ethical and efficient approaches to basic and applied research in the fields of environmental toxicology, drug development, and neuroscience. In this episode I talk with Thomas about tw…
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Someday it may be possible to restore neuronal networks that have been lost or damaged by brain injury or in neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. There are as many astrocytes in the human brain as there are neurons and the astrocytes generally do not die in brain injuries and neurodegenerative disorders. Profess…
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The Euclidean geometry that we learned in our primary education concerns man-made shapes such as rectangles, triangles, and perfect circles. However the shapes of molecules, cells, and organ systems (and their dynamic changes over time) are more complex. Some biological structures exhibit fractal geometry which is defined as “shapes and patterns th…
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Polyamines are small organic molecules that are acquired in the diet and can also be synthesized in cells. Spermidine is a polyamine that is increasingly recognized as playing important roles in counteracting aging. Foods with high amounts of spermidine include whole grains, broccoli, and natto (fermented soybeans). Professor Stephan Sigrist at the…
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In the moment most people can readily distinguish between information that is coming into the brain from their senses and what information their brain is generating. However, when recalling information stored in the brain’s neuronal networks the ability to distinguish between what was real and what was imagined becomes more problematic. How does th…
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In this episode Emory University and Chinese Academy of Sciences Professor Keqiang Ye talks about his fascinating and ground-breaking trail of discoveries that have revealed previously unknown mechanism responsible for the production and accumulation of damaging fragments of the APP and Tau proteins in Alzheimer’s disease (AD) and the alpha-synucle…
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Among high income countries the United States spends the most on health care and yet has the lowest life expectancy. A high percentage of Americans suffer with chronic diseases including obesity, diabetes, cardiovascular disease, mental disorders, and Alzheimer’s or Parkinson’s diseases. There are several reasons why people living in the wealthiest…
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In this episode I talk with Professor Jason Shepherd about his discoveries concerning a fascinating protein called Arc. In response to synaptic activity Arc levels rapidly increase in postsynaptic dendrites as a result of local translation of the Arc mRNA in the dendrites. Arc plays a critical role in long-term memory although it is not necessary f…
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Among high income countries the United States spends the most on health care and yet has the lowest life expectancy. A high percentage of Americans suffer with chronic diseases including obesity, diabetes, cardiovascular disease, mental disorders, and Alzheimer’s or Parkinson’s diseases. There are several reasons why people living in the wealthiest…
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Season 23, Episode 11: Brew Session (Duskmourn & Foundations Potpourri) David weighs in on the controversy around the NV Invitational and the Feast of the $100,000 Alpha starter, and shares 7 fresh brews. Decklists for this episode can be viewed at FaithlessBrewing.com Like our content? Support us on Patreon and join our Discord community!…
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Humans have the amazing ability to instantly recognize the faces of hundreds or even thousands of people they have previously met or seen in pictures or movies. Studies of people with brain injuries that render them incapable of recognizing faces and recordings of neuronal activity in people during face recognition have shown that networks in the o…
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In this final episode of the Bioenergetics and Brain Health series I talk about changes that occur in brain cells during normal aging, and in Alzheimer’s disease, Parkinson’s disease, and stroke with emphasis on alterations upstream and downstream of cellular energy metabolism. The episode concludes with examples of therapeutic interventions that t…
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Season 23, Episode 10: The NV Invitational "Some delicacies are not to be savored, save by the callous" —Baron Sengir Just in time for the Thanksgiving holiday, we invite you to a sumptuous feast of MTG nostalgia. If you possessed an Alpha starter deck, what would you do with it? Would you keep it locked safe in a vault, preserving its possibilitie…
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In this third podcast in the Bioenergetics and Brain Health series I talk about how intermittent exercise and fasting affect brain function, neuroplasticity, and resilience. Research has shown that both of these bioenergetic challenges can enhance learning and memory, improve mood, counteract aging, and protect neurons against injury and disease. I…
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