Best Josh Mattson Podcasts (2025)

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211. Susan Lyne Part 1 50:01

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1h ago50:01

50:01

I’ve maybe never interviewed anyone in my entire time as a historian and podcaster who has had a career as broad and varied as Susan Lyne. Yes, I obviously wanted to talk to Susan about her role helping startup Gilt Group, and her current role as the managing partner of the VC firm BBG Ventures. But, holy how. Susan also launched and oversaw the go…

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210. Esther Dyson 1:10:03

1d ago1:10:03

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In the more than 200 episodes I’ve done for this podcast, never has the designation “legend” been more appropriate. Esther Dyson is a legend of modern technology, having been present for so many key moments from the early PC era through to the AI era. She’s advised, interviewed and mentored basically every major tech figure over the last several de…

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David Gutmann – Cancer Neuroscience and the Sociobiology of Brain Tumors 59:27

13d ago59:27

59:27

Brain tumor cells interact with neurons, glial cells, and immune cells in complex ways that often benefit the cancer cells while compromising the function of normal neural cells. In this episode I talk with Washington University Neurology Professor David Gutmann about brain cancer cells and their communication with surrounding normal cells. A major…

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209. Henry Blodget, Founder Of Business Insider 1:05:34

12d ago1:05:34

1:05:34

Henry Blodget shares his journey from a history major to a prominent figure in finance and journalism, discussing the rise of the internet, the dot-com bubble, and the lessons learned from that era. He reflects on his career, including his famous $400 price target Amazon prediction, the evolution of media with the launch of Business Insider, and th…

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Ray Dorsey: Environmental Toxins and Parkinson's Disease – Evidence and What to Avoid 57:26

19d ago57:26

57:26

There is considerable evidence that exposure to certain chemicals in the environment cause Parkinson's disease in many people. In this episode neurologist Ray Dorsey talks about some of the chemicals that may cause Parkinson's disease including the pesticides paraquat and rotenone, and trichloroethylene and perchloroethylene which are chemicals use…

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208. Clément Delangue Of Hugging Face 53:59

22d ago53:59

53:59

Hugging Face Founder Clément Delangue discusses his journey to founding Hugging Face, emphasizing the importance of community, collaboration, and open-source technology in the AI landscape. He reflects on the evolution of AI technology, the significance of user feedback, and the need for a diverse range of AI models. Takeaways Clem's first compute…

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207. John Borthwick Of Betaworks 56:53

28d ago56:53

56:53

John Borthwick shares his journey from a tech-savvy youth to a prominent figure in the New York tech scene. He discusses his early experiences with computers, the transformative impact of the World Wide Web, and the vibrant tech culture of the 90s. Borthwick reflects on his role in creating Total New York, the lessons learned from the AOL acquisiti…

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Ai Yamamoto: "ALFY" Cleanses Neurons of Pathological Proteins to Counteract Degenerative Diseases 1:12:11

1M ago1:12:11

1:12:11

A shared feature of neurodegenerative disorders is accumulation of aggregated proteins within neurons: Tau in Alzheimer's disease; alpha-synuclein in Parkinson's disease; huntingtin in Huntington's disease; and TDP43 in amyotrophic lateral sclerosis. In this episode Ai Yamamoto – an Associate Professor Neurology at Columbia University – talks about…

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206. Jimmy Wales, Founder Of Wikipedia 1:14:32

1M ago1:14:32

1:14:32

Welcome BACK to the Internet History Podcast. After essentially a 5 year hiatus, the Internet History Podcast is back, fully back, a whole slate of episodes coming to you, and I couldn’t be more thrilled to have our relaunch episode be with Jimmy Wales. What can I tell you? He’s the founder of Wikipedia. We get deep into the history of all that but…

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205. Margit Wennmachers Of a16z 1:04:38

1M ago1:04:38

1:04:38

People know that a16z changed tech by turning VCs and founders into rock stars. You know the names. But there’s one name you might not know, that real heads, deep inside the industry have known very well over the years. The legend, Margit Vennmachers. You know all those a16z names because of Margit, because of how she helped Marc Andreessen and Ben…

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204. Fred Wilson, Of Union Square Ventures 1:03:03

1M ago1:03:03

1:03:03

For my entire career in tech and startups, Fred Wilson has been like the god-level VC in the New York City ecosystem. Fred got his start investing before the dotcom bubble, rode the bubble investing in the earliest internet companies to great success, and then turned Union Square Ventures into the premier venture capital firm on the east coast. Hea…

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Marco Capogrosso – Spinal Cord Stimulation for Recovery of Function After Stroke or Trauma 1:03:16

1M ago1:03:16

1:03:16

Remarkable advances are being made in the development and clinical applications of stimulation devices that enable recovery of motor function in patients who have suffered a spinal cord injury, a stroke, and even those with rare disabling genetic disorders. At the forefront of this research is Marco Capogrosso at the University of Pittsburgh. He ha…

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Scott Ayton: Iron, Brain Health, Parkinson's and Alzheimer's Diseases – A Delicate Balance 1:15:26

2M ago1:15:26

1:15:26

Dietary iron is essential for health as it plays important roles in the ability of hemoglobin to carry oxygen throughout the body and brain. In addition, iron is involved in various functions in cells including the generation of ATP in mitochondria and DNA synthesis. The vast majority of iron is bound to proteins such as ferritin and heme. However,…

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Erik Musiek: Brain Cell Circadian Clock Proteins in Neuroplasticity, Aging, and Alzheimer's Disease 1:12:00

2M ago1:12:00

1:12:00

Health depends upon proper regulation of circadian rhythms of cell and organ functions. Disruption of circadian rhythms has detrimental consequences for brain function and resilience and abnormal circadian rhythms are a common feature of Alzheimer's disease. In this episode neurology professor Erik Musiek talks about the roles of specific circadian…

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Georgia Hodes: Sex Differences in Responses to Stress and Vulnerability to Neurological Disorders 1:11:08

3M ago1:11:08

1:11:08

Chronic uncontrolled stress is a risk factor for many different diseases including mental and neurodegenerative disorders. The effects of such stress on the brain differ considerably between females and males. However, the vast majority of preclinical studies in animal models have included only males which in some cases has resulted in therapeutic …

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Quest Me Revisits The Book Of Boba Fett w/ Ro! 1:26:15

3M ago1:26:15

1:26:15

Welcome back to Quest me! The Star Wars Podcast that takes you on a quest through legends and new canon! The boys are going back to Tatooine to revisit one of the more controversial Star Wars series; The Book Of Boba Fett! Ro comes along for the ride to talk about how the series holds up, what could have been, and how Legends compares to the New Ca…

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Marian Joëls and Ron de Kloet: How the Brain Responds to Stress in Health and Mental Disorders 1:14:54

3M ago1:14:54

1:14:54

In stressful situations the brain communicates with the adrenal glands stimulating them to release adrenaline and cortisol. This stress responsive neuroendocrine system plays important adaptive roles by regulating energy metabolism, attention, and learning and memory. However, without a recovery period chronic uncontrolled stress such as psychosoci…

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Dad Went to the Store Part 2 1:11:38

3M ago1:11:38

1:11:38

Welcome to The Very Best: A Pokecast! The podcast dedicated to discussing and learning about everything Pokemon! Roy is out again this week so Shay and Josh take the wheel again! This week they're covering the Pokemon World Championships, the new TCGP set, some new deck builds, and much more! The crew also breaks down episodes 28 and 29 of the orig…

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The Jedi Academy Trilogy 2:08:18

3M ago2:08:18

2:08:18

Welcome back to Quest me! The Star Wars Podcast that takes you on a quest through legends and new canon! On this weeks quest we dive in to the Legends series; The Jedi Academy Trilogy by Kevin J Anderson! We look at how far the #StarWars universe has come since 1994 and what has changed. We also ask the question, "Have we been pronouncing things wr…

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Josh Helman: Multipronged Approaches for Preventing and Treating Alzheimer's Dementia 59:38

3M ago59:38

59:38

Clearly demonstrated as being effective for cardiovascular disease, lifestyle medicine is becoming an important discipline for the prevention and treatment of age-related brain disorders including Alzheimer's and Parkinson's diseases. In this episode I talk with Dr. Josh Helman about his experience working with patients at lifestyle medicine center…

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Grace (Beth) Stutzmann: Pivotal Role for Calcium in Brain Aging and Alzheimer's Disease 53:14

4M ago53:14

53:14

The calcium ion controls neuronal network activity, synapse function and synaptic plasticity, and is a fundamental mediator of learning and memory. With aging and much more so in Alzheimer's disease the ability of neurons to properly regulate their intracellular calcium levels becomes compromised. Evidence from human and laboratory animal studies h…

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Dad Went To The Store 1:02:22

4M ago1:02:22

1:02:22

Welcome to The Very Best: A Pokecast! The podcast dedicated to discussing and learning about everything Pokemon! Roy is off this week so Shay and Josh do their very best to keep the show together. From discussions about the Pope to the latest TCGP sets, the crew is covering everything Pokemon this week including their review of Episode 26(Hypnos Na…

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Andrew Dillin – Stress and Aging: Mitochondria are Hubs of Information Flow in and Between Cells 49:00

4M ago49:00

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Long believed to function only as the cell's powerhouse research is revealing that mitochondria actively control a cell's response to various types of stress. Even more amazingly mitochondria send stress-related signals between cells. In this episode UC Berkeley Professor Andy Dillin has made major advances in understanding basic mechanisms of agin…

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Pokemon Presents July 22nd 1:18:28

4M ago1:18:28

1:18:28

Welcome to The Very Best: A Pokecast! The podcast dedicated to discussing and learning about everything Pokemon! This week were talking about all the news and updates that came out of the Pokemon Presents on July 22nd! Follow The Very Best on your favorite Social Media app! FACEBOOK TIKTOK BLUESKY YOUTUBE TWITCH Closing Music by Nicholas Panek via …

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Marc Freeman – How Astrocytes Control Neural Circuits in Brain Development, Plasticity, and Disease 1:18:41

4M ago1:18:41

1:18:41

While neurons and the circuits the form have been the major focus of brain research the human brain contains at least as many cells that are not neurons of which astrocytes are by far the most abundant. During the past decade there have been numerous studies that reveal novel and very active roles for astrocytes in regulating the growth of neurons,…

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Darth Plagueis & The Acolyte(1 Year Later) 1:19:51

4M ago1:19:51

1:19:51

Welcome back to Quest me! The Star Wars Podcast that takes you on a quest through legends and new canon! The boys are back in town to discuss one of the most storied Sith in the Star Wars galaxy, Darth Plageous We also look into the acolyte 1 year later. Did it work? Do our reviews hold up? Join us live on Saturdays and sometimes Sundays at 9:30pm …

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Polina Shichkova: Metabolic and Biophysical Modeling of Breakdown and Repair of the Aging Brain 1:03:05

4M ago1:03:05

1:03:05

Because neurons in the brain are electrically excitable and active 24/7 the brain consumes relatively large amounts of energy and must adapt to varying demands on its neural networks. The cellular and molecular complexity of the brain presents a major challenge for understanding not only its second-by-second function but also how neural networks ar…

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Corinde Wiers: The Potential of Ketone-Based Interventions for the Treatment of Addiction 1:07:26

5M ago1:07:26

1:07:26

Research on substance use disorders has largely focused on understanding the key neural circuits and neurotransmitter systems that are altered, and on behavioral and pharmacological interventions. However, emerging research findings suggest that alcohol use disorder (AUD) is associated with alterations in energy metabolism and can accelerate brain …

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Henning Fenselau – Neural Circuits Controlling Appetite and Energy Metabolism and GLP-1 Actions 56:52

5M ago56:52

56:52

Appetite (hunger and satiety) is controlled by neural circuits in the brain – particularly in the hypothalamus – and their reciprocal connections to peripheral organs involved in energy metabolism (gut and liver). Understanding the structural organization of these circuits (their synaptic connections) and their neurochemistry (particularly which ne…

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Tessa Montague: Disappearing Act - How the Brain Controls Camouflage in Cuttlefish and Octopuses 1:09:01

5M ago1:09:01

1:09:01

One of the most remarkable feats of biological 'wizardry' in the animal kingdom is the ability of some cephalopods (octopuses, squids, and cuttlefish) to rapidly change the color, patterning, and texture of their skin so as to blend in with their background. They accomplish these feats through the linking of neural circuits in the visual system and…

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The Boys are Haters! 1:14:11

5M ago1:14:11

1:14:11

Welcome to The Very Best: A Pokecast! The podcast dedicated to discussing and learning about everything Pokemon! This week we are breaking down some more Pokemon news and discussing the new Gamefreak game thats not pokemon? We also talk about the new TCGP Eevee set that was recently released, build Shay a pokemon team and breakdown episodes 24 and …

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The Mortis Gods 1:14:41

5M ago1:14:41

1:14:41

Welcome back to Quest me! The Star Wars Podcast that takes you on a quest through legends and new canon! This week we are talking about the Mortis Gods or The Ones! Who are they? What do they do? Will they be back and have we seen a reincarnation of them already? We also look into some Star Wars news/rumors and talk about the future of Star wars! J…

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Jonathan Long: Lactate-Phe and Ketone-Phe: Exerkines and Fastokines for Brain Health and Plasticity? 1:02:26

5M ago1:02:26

1:02:26

During vigorous exercise lactic acid (lactate) levels increase in the blood and during fasting and extended exercise the levels of the ketone BHB (b-hydroxybutyrate) increase. In this episode I talk with Stanford University professor Jonathan Long about his recent discovery that lactate and BHB in the blood are bound to the amino acid phenylalanine…

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Carlos Matute: Brain White Matter in Health, Endurance Exercise, and Disease 1:17:20

6M ago1:17:20

1:17:20

White matter consists of bundles of long axons that convey information between neural circuits between different brain regions within and between brain hemispheres. These long axons are wrapped with many layers of lipid-rich membranes of oligodendrocytes (a type of glial cell) and it is this 'insulation' that enables rapid propagation of signals ov…

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The G Boys 1:21:06

6M ago1:21:06

1:21:06

Welcome to The Very Best: A Pokecast! The podcast dedicated to discussing and learning about everything Pokemon! This week we are talking about some pokemon news, Our experience with Magic The Gathering, Roys shiny new Switch 2, and alot more! We also continue our Pokemon; The Indigo League rewatch and breakdown episodes 22 & 23 causing Josh to hav…

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The World Between Worlds 1:09:43

6M ago1:09:43

1:09:43

Welcome back to Quest me! The Star Wars Podcast that takes you on a quest through legends and new canon! Join us as we go on a quest through the world between worlds! Ro, from the Scariff Scuttlebutt Podcast also comes along to ask all the questions and try to figure out what the heck the World Between Worlds really is! Join us live on Saturdays an…

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Michael Kreutz: Amazing Nanomachines in Synapses that Keep Brains Healthy and Wise 1:01:28

6M ago1:01:28

1:01:28

Michael Kreutz is Head of the Neuroplasticity Research Group at the Leibniz Institute for Neurobiology in Magdeburg Germany. Using powerful high resolution microscopy and molecular biology tools his laboratory has shown that autophagy occurs within synapses. Synaptic autophagy is stimulated by neural network activity and is critical for their maint…

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Jordan Grafman: Neural Circuits of Religiosity: 'The Kingdom of God' is in the Prefrontal Cortex 1:11:17

6M ago1:11:17

1:11:17

Belief in supernatural agents and other religious myths arose as a means of 'explaining' the unknown and as a tool for social cohesion and hierarchical control of civilizations. Their religiosity is major feature of a 'believers' self identity as well as their group identity. Compelling evidence from multiple types of studies have revealed the neur…

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Who is the Guzzlord? 1:38:11

6M ago1:38:11

1:38:11

Welcome to The Very Best: A Pokecast! The podcast dedicated to discussing and learning about everything Pokemon! Were back! We took a little break so Josh could go off to a galaxy far far away but this week we are back and talking about all the news we missed along with the next 2 episodes of #pokemon the indigo league! Quest Me Link- Check out Jos…

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Sridevi Sarma: Using DSM and Neuro-engineering to Diagnose and Treat Neurological Disorders 52:43

6M ago52:43

52:43

Neurological disorders involve aberrant neural network activity. New technologies are needed for establishing at a fine spatial and temporal resolution the nature of the altered network activity – and for restoring activity to or towards a healthy state. Professor Sri Sarma is an electrical engineer and neuroscientist who is at the forefront of thi…

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Quest Me Reviews Rogue One 1:42:22

6M ago1:42:22

1:42:22

Welcome back to Quest me! The Star Wars Podcast that takes you on a quest through legends and new canon! This season we are reviewing season two of Andor! On this weeks episode of Quest Me, Josh, Justin and Phil are all discussing Rogue one: A Star Wars Story and how it has changed since finishing the Andor Series! Join us live on Saturdays and som…

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How Legends Are Made 2:15:14

6M ago2:15:14

2:15:14

Welcome back to Quest me! The Star Wars Podcast that takes you on a quest through legends and new canon! This season we are reviewing season two of Andor! Its the Finale of greatness and Josh, Phil, and Justin are breaking it down for you! Join us for a quest through the Andor Season 2 Finale! How does it hold up in the Star Wars galaxy? Is Andor t…

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Richard Johnson: How High Fructose Intake Induces Obesity and Chronic Diseases of the Body and Brain 1:09:28

6M ago1:09:28

1:09:28

Compelling evidence shows that consumption of high fructose corn syrup in soft drinks and ultraprocessed foods has contributed to the increases in obesity, diabetes, fatty liver disease, and dementia that has occurred during the past 50 years. Professor Richard Johnson's research has been at the forefront of establishing how fructose adversely affe…

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Star Massacres 2:24:38

7M ago2:24:38

2:24:38

Welcome back to Quest me! The Star Wars Podcast that takes you on a uest through legends and new canon! This season we are reviewing season two of Andor! Justin is back! He also brought our good friend Steve(Sinecera) along with him to discuss Andor Season 2! This week were breaking down the third arc of andor and asking the question, "Is this the …

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Brian Kennedy: Decoding Metabolic Aging Clocks to Understand and Counteract Aging 1:20:19

7M ago1:20:19

1:20:19

Major progress has recently been made in understanding the aging process at the molecular, cellular, and organ system levels. This knowledge is now being applied in preventative and interventional health care. Moreover, because of the severe burden of age-related diseases on societies governments are increasingly developing strategies to extend hea…

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Spy Wars! 1:35:13

7M ago1:35:13

1:35:13

Welcome back to Quest me! The Star Wars Podcast that takes you on a uest through legends and new canon! This season we are reviewing season two of Andor! Unfortunately Justin is not with us this episode but we do get to talk about his quotes as Josh and Phil break down the second arc of Andor Season 2! Join us live on Saturdays at 9:30pm CST/8:30pm…

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Anton Maximov – The Synaptic Signatures of a Memory: Zooming in Using Cutting-Edge Technology 1:36:52

7M ago1:36:52

1:36:52

Remarkable progress has been made towards understanding of the molecular control of neurotransmitter release from presynaptic axon terminals and the responses of the postsynaptic neuron by neurotransmitters. We know that synaptic activity is required for learning and memory but the structural basis of a memory (an engram) remains unknown. Anton Max…

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Pokemon With Rivals Pt. 2 1:23:39

7M ago1:23:39

1:23:39

Welcome to The Very Best: A Pokecast! The podcast dedicated to discussing and learning about everything Pokemon! On this weeks episode Shay is on vacation and Jesse is back and ready to correct all of our wrongdoings. We also break down the news and updates from the last week and build a team for Professor Snape! Gangplank Galleon Cover by Thunderc…

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Allan Butterfield: Cell Membrane Lipid Peroxidation and Neuron Degeneration in Alzheimer's Disease 1:30:42

7M ago1:30:42

1:30:42

The outer membrane of cells is comprised of a lipid bilayer consisting of phospholipids, cholesterol, arachidonic acid, omega-3 fatty acids, and others. Embedded in the membrane are various proteins that play roles critical to the survival and function of the cell. Examples of membrane proteins of particular importance for neurons are: ion channels…

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Surprise! Andor is Good! 1:42:38

7M ago1:42:38

1:42:38

Welcome back to Quest me! The Star Wars Podcast that takes you on a uest through legends and new canon! This season we are reviewing season two of Andor! Unfortunately Justin is not with us this episode but Phil and Josh break down the first three episodes of Andor Season 2! Join us live on Saturdays at 9:30pm CST/8:30pm MST to talk about the lates…