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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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“HATE. LET ME TELL YOU HOW MUCH I'VE COME TO HATE YOU SINCE I BEGAN AS A HAEM REG. IF THE WORD HATE WAS ENGRAVED ON EACH NANO-ANGSTROM OF THE HUNDREDS OF MILLIONS OF CONSULT NOTES I HAVE WRITTEN IT WOULD NOT EQUAL ONE BILLIONTH OF THE HATE I FEEL FOR YOU ORDERING THROMBOPHILIA TESTING INAPPROPRIATELY.” Woah - Let’s calm down, that's a bit much. Cale and Bashar are exposed to Nick’s inner monologue as the Bloody Minded Crew learn about the what, when and when not of thrombophilia testing.
TIMESTAMPS
0:52 - Nick gets stuck in an anger loop
2:19 - Intro to thrombophilia testing
4:25 - Inherited thrombophilias
5:38 - Surprise historical diversion on antithrombin
8:14 - Proteins C and S
9:31 - Factor V Leiden
10:56 - Prothrombin gene mutation
11:52 - Risk profiles in inherited thrombophilia
18:49 - Acquired thrombophilias
18:56 - Antiphospholipid syndrome
19:46 - PNH
20:22 - JAK2
21:08 - Mid-ep summary
22:28 - The world's biggest soapbox: what not to do
23:25 - Soapbox: no MTHFR pls
25:19 - Soapbox: bad times to test
26:46 - Soapbox: don't test the obvious provoked clots
27:30 - Bonus soapbox: factor V levels vs Leiden
28:54 - When SHOULD we test?
30:41 - Benefits of testing
32:33 - Clinical scenario: spoiler, no real answer
33:26 - Scenarios where you might test
37:49 - Take home messages
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Chapters
1. Episode 69 - I Have No Brain And I Must Test | Thrombophilia Testing (00:00:00)
2. Nick gets stuck in an anger loop (00:00:52)
3. Intro to thrombophilia testing (00:02:19)
4. Inherited thrombophilas (00:04:25)
5. Surprise historical diversion on antithrombin (00:05:38)
6. Proteins C and S (00:08:14)
7. Factor V Leiden (00:09:31)
8. Prothrombin gene mutation (00:10:56)
9. Risk profiles in inherited thrombophilia (00:11:52)
10. Acquired thrombophilias (00:18:49)
11. Antiphospholipid syndrome (00:18:56)
12. PNH (00:19:46)
13. JAK2 (00:20:22)
14. Mid-ep summary (00:21:08)
15. The world's biggest soapbox: what not to do (00:22:28)
16. Soapbox: no MTHFR pls (00:23:25)
17. Soapbox: bad times to test (00:25:19)
18. Soapbox: don't test the obvious provoked clots (00:26:46)
19. Bonus soapbox: factor V levels vs Leiden (00:27:30)
20. When SHOULD we test? (00:28:54)
21. Benefits of testing (00:30:41)
22. Clinical scenario: spoiler, no real answer (00:32:33)
23. Scenarios where you might test (00:33:26)
24. Take home messages (00:37:49)
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