Anxiety and Depression are linked with inflammation. Key regulator of the cellular antioxidant response NRF2 may play a role. Discover how an ancient herbal formula may help us better understand the relationship between depression and inflammation as well as the role of metabolites as possible biological markers for more objective diagnosis of major depression. Xiao Yao Chapter of Zhuangzi https://ctext.org/zhuangzi/enjoyment-... Xiong, Xingjiang, et al. "Efficacy and safety of Chinese herbal medicine Xiao Yao San in hypertension: a systematic review and meta-analysis." Phytomedicine 61 (2019): 152849. Liu, Xiaojie, et al. "Plasma metabolomics of depressed patients and treatment with Xiaoyaosan based on mass spectrometry technique." Journal of ethnopharmacology 246 (2020): 112219. Ma Q. (2013). Role of nrf2 in oxidative stress and toxicity. Annual review of pharmacology and toxicology, 53, 401–426. https://doi.org/10.1146/annurev-pharm... Chen, Jia-Xu, et al. "Effects of Chai Hu (Radix Burpleuri) containing formulation on plasma β-endorphin, epinephrine and dopamine in patients." The American Journal of Chinese Medicine 33.05 (2005): 737-745. Martín-de-Saavedra, María Dolores, et al. "Nrf2 participates in depressive disorders through an anti-inflammatory mechanism." Psychoneuroendocrinology 38.10 (2013): 2010-2022. Martín-de-Saavedra, María Dolores, et al. "Nrf2 participates in depressive disorders through an anti-inflammatory mechanism." Psychoneuroendocrinology 38.10 (2013): 2010-2022. *Correction: At 8:10 I say 2,000 years. That should be 1,000 years. The formula its based on if nearly 2,000 years old being created at around AD 190.