))
Methylene Blue and the Bioenergetics of Memory
Manage episode 490481446 series 3635277
In this episode of Daily Value, we look at the neurometabolic potential of methylene blue, a synthetic dye first synthesized in the 19th century, for supporting brain energy metabolism during aging. Originally developed for textile use, methylene blue has since demonstrated potential use as a redox-active agent in neuroprotection and memory enhancement (and how exactly it performs these actions).
We look at it’s unique biochemical mechanism as an alternative electron carrier within the mitochondrial electron transport chain, showing how it may bypass dysfunctional complexes to enhance ATP production and reduce oxidative stress.
The episode also discusses findings from animal models and human trials, including the challenges and inconsistencies observed in clinical studies - along with potential risks, contraindications, and the implications for aging-related cognitive decline.
00:00 Introduction to Methylene Blue
00:57 Historical Background and Early Uses
02:31 Methylene Blue in Modern Medicine
04:03 Mechanisms of Action in the Brain
05:59 Dosage and Effects
12:23 Human Studies and Clinical Trials
15:35 Safety Concerns and Contraindications
18:16 Conclusion and Future Directions
PMID: 22067440
PMID: 34943887
PMID: 38022191
PMID: 36803299
Chapters
1. The 19th Century Dye's Promise (00:00:00)
2. History and Applications of Methylene Blue (00:01:34)
3. Mitochondrial Dysfunction in Brain Aging (00:04:02)
4. Methylene Blue's Memory Enhancement Mechanisms (00:07:16)
5. Clinical Trials and Mixed Results (00:12:16)
6. Safety Concerns and Contraindications (00:15:35)
7. Episode Summary and Conclusion (00:19:04)
51 episodes
Share
