Share
))
HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
…
continue reading
Manage episode 522274624 series 3635277
Content provided by Dr. William Wallace. All podcast content including episodes, graphics, and podcast descriptions are uploaded and provided directly by Dr. William Wallace or their podcast platform partner. If you believe someone is using your copyrighted work without your permission, you can follow the process outlined here https://staging.podcastplayer.com/legal.
A new brain-imaging meta-analysis has uncovered the first consistent biochemical signature across multiple anxiety disorders (a shift in a single molecule that moves in the opposite direction of every major psychiatric condition studied to date). Even more surprising, a separate study in young adults under metabolic strain reveals a nearly identical pattern emerging outside the brain. In this episode, we trace the science behind this unexpected overlap, follow the trail of this overworked molecule, and explore what these clues suggest about the hidden biology anxiety leaves behind.
00:00 A New Chemical Clue in Anxiety Disorders
00:33 How Common Anxiety Really Is — and Why It’s Hard to Treat
01:24 A Biochemical Pattern That Reverses Every Expectation
02:52 The Molecule Behind the Cortical Signal
04:26 What Chronic Stress Does to This Molecular Pathway
08:13 How to Support the Brain Systems This Molecule Serves
09:20 Final Thoughts: Caring for the Biology Behind Anxiety
PMID: 40913113
PMID: 26886842
PMID: 19656836
PMID: 41296930
Chapters
1. A New Anxiety Signature (00:00:00)
2. Why Treatment Falls Short (00:00:33)
3. Rethinking Anxiety Biology (00:00:54)
4. The Meta-Analysis Surprise (00:01:27)
5. Metabolic Stress Echoes The Pattern (00:02:09)
6. Unusual Direction Of Change (00:02:30)
7. From Behavior To Brain Chemistry (00:02:30)
8. What MRS Actually Measures (00:02:47)
9. Choline Signal Runs Low (00:03:17)
10. How Big Is An 8% Shift? (00:04:10)
11. Why Would Choline Drop? (00:04:30)
12. Noradrenaline’s Triple Pull (00:06:04)
13. The Bodywide Echo In Blood (00:06:14)
14. What It Means For You (00:06:33)
15. How Much Choline You Need (00:07:05)
16. Food Sources That Hit The Target (00:08:13)
17. Food First, Systems First (00:09:10)
18. A Hopeful Closing (00:09:39)
70 episodes
