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Ever feel intensely itchy but your skin is clear (without any rash)?

You could have neuropathic itch—a type of chronic itch caused by nervous system dysfunction, not inflammation. Unlike eczema or hives, this itch appears without a rash. It can be so severe that it leads to skin damage from scratching, yet it’s often misdiagnosed or overlooked.

Joining me to unpack this under-recognized condition is Dr. Shawn Kwatra, Chair of Dermatology at the University of Maryland and author of Living with Itch. He shares what we know so far, why treatment is so tricky, and what research is uncovering about neuropathic itch.

⭐️Mentioned in This Episode:

- Find Dr. Shawn Kwatra online - https://www.kwatralab.org/

- Neuropathic Itch paper - https://www.jacionline.org/article/S0091-6749(23)00510-9/pdf

- Get Dr. Kwatra's book, Living with Itch: A Patient's Guide: https://a.co/d/h5B3fjl

- Join in the conversation with Jennifer at http://instagram.com/jenniferfugo

- Stop My Rashes FREE eGuide - https://bit.ly/stopmyrashespod

- Fix your skin using Jennifer’s method (trusted by 900+ skin rash warriors)! Get started NOW 👉https://gutskintriggers.com

- Want personalized help to fix your skin? Get started here with Jennifer’s virtual clinic 👉https://bit.ly/4iWrq62 (We work with clients worldwide!)

🎙 This episode is brought to you by:

Quell Essentials Skincare + Supplements for Sensitive Skin 👉https://www.quellshop.com use code POD15 for 15% off

Ready to figure out your skin’s root causes so you can finally fix your skin + break free from meds to manage your skin?

My virtual clinic works with adults worldwide struggling with eczema, psoriasis, rosacea, urticaria, hives, dandruff, perioral dermatitis + more.

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Schedule an assessment call at
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Chapters

1. Introduction (00:00:00)

2. What causes itchy skin without rash? (00:03:23)

3. Brain connection to itchy skin (00:08:36)

4. Examples of neuropathic itch (skin itching without rash) (00:12:21)

5. Treatment options for neuropathic itch (00:16:26)

6. Which inflammatory cytokines are involved? (00:20:26)

7. Could Low Dose Naltrexone help? (00:23:06)

8. Alternative therapies for neuropathic itch (00:27:01)

9. Final thoughts (00:30:46)

399 episodes