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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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In this episode of The Y in Psychiatry, Dr. Amayo, Dr. V Handratta, and Dr. Nguyen take bipolar disorder off the DSM page and into your brain, but through your ears. They explain through tracing how dopamine and serotonin imbalances map onto psychomotor agitation, depression, and that “too much energy” feel of mania. They fly through the basal ganglia–thalamus–sensorimotor loop, the ventrolateral and ventromedial prefrontal cortex, the amygdala, and the superior frontal gyrus to show how disrupted circuits drive impulsivity, hyperemotionality, and goal-directed behavior. Say that 10 times. Along the way, they drop practical mnemonics, callbacks to network neuroscience, and framing you can use at the bedside or on rounds—no fMRI in clinic required.
https://www.nguyenindoubt.com/theyinpsych
https://feeds.buzzsprout.com/2185312.rss
Chapters
1. Nerdy cold open & show intro (00:00:00)
2. Why in bipolar disorder: setting the stage (00:00:58)
3. Monoamine hypothesis in bipolar (00:01:26)
4. Circuits for restlessness: basal ganglia → thalamus → motor cortex (00:03:52)
5. Ventrolateral PFC & inferior frontal gyrus: impulsivity and prosody (00:07:20)
6. Ventromedial PFC & limbic “brakes off” (00:09:51)
7. Amygdala overactivation & sympathetic arousal (00:10:52)
8. Superior frontal gyrus & energization (00:12:10)
9. Network view: you can’t tweak one node (00:13:57)
10. Recap, visualization tips & teaser for meds (00:15:35)
20 episodes
