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HBO and The Ringer's Bill Simmons hosts the most downloaded sports podcast of all time, with a rotating crew of celebrities, athletes, and media staples, as well as mainstays like Cousin Sal, Joe House, and a slew of other friends and family members who always happen to be suspiciously available.
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Notes
Hemodynamics is the key to understanding tissue perfusion and oxygen delivery.
Cardiac output (CO) = Stroke volume (SV) × Heart rate (HR). Normal range: 4-8 L/min.
Cardiac index (CI) normal range: 2.5-3.5 L/min/m². CI adjusts CO for body surface area (BSA).
Stroke volume (SV) normal range: 60-100 mL/beat, influenced by preload, afterload, and contractility.
Preload: Volume of blood in the ventricle before contraction; assessed with central venous pressure (CVP) and pulmonary capillary wedge pressure (PCWP).
Afterload: The resistance the heart must overcome to eject blood; influenced by systemic vascular resistance (SVR).
Contractility: The strength of the heart muscle contraction; assessed through cardiac index (CI) and ejection fraction (EF).
Key interventions: Fluid boluses for low preload, diuretics for high preload, vasopressors for low afterload, and inotropes for low contractility.
Dynamic assessments like passive leg raise (PLR) help determine fluid responsiveness, reducing over-resuscitation.
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