In this episode of Walk, Don't Run to the Doctor, we take a deep dive into statins, their true benefits, their real risks, and the massive role lifestyle plays in shaping heart disease outcomes. Rather than accepting oversimplified medical advice, this episode empowers you to think critically, understand uncertainty in medicine, and make fully informed decisions about your own health. You'll learn how to interpret risk statistics (like relative vs absolute risk), why lifestyle may outperform medication for many people, and why statins are helpful for some—yet potentially unnecessary or harmful for others. If you've ever been told "your cholesterol is high, you need a statin," this episode will give you the tools to ask better questions and understand whether that advice truly applies to someone like you. Key Takeaways: -Medical uncertainty is real — many "facts" are actually opinions without solid or applicable evidence. -Statins help some people more than others: -Strong evidence for people who already had a heart attack. -Much smaller benefit (sometimes minimal) for healthy, active people without prior heart disease. -Absolute vs. relative risk matters: -A "25% reduction in risk" may really mean only 1 fewer event per 100 people. -Lifestyle changes can reduce risk by 50–80%, often outperforming statin benefits—especially for people who exercise, eat whole foods, avoid smoking, keep weight down, and drink moderately. -Statin risks are real: Muscle pain: up to 1 in 10 Diabetes risk increased: about 1 in 200 Possible cognitive impairment (enough for an FDA warning) Polypharmacy (multiple medications) increases uncertainty and side-effect risks. Get your copy of Good Food Great Medicine, 4th ed.: https://a.co/d/1D6hIYM More references can be found at www.GreatMed.org Would you like Dr. Hassell to answer your question on the air? Contact us! Phone/text: 503-773-0770 e-mail: [email protected] EIN: 88-326-7056 Write us a letter. We love to hear from you. This podcast is sponsored by our generous listeners. Send questions, comments, and support to: GreatMed.org 4804 NW Bethany Blvd., Suite I-2, #273 Portland OR 97229 Check out this video on Completely Rethinking the Link Between Statins, Cholesterol, & Heart Disease, w/ Dr. Aseem Malhotra: https://www.youtube.com/watch?v=-RU3Ouxt1vs&t=251s References from today's podcast: Ioannidis J. P. (2005). Why most published research findings are false. PLoS medicine, 2(8), e124. https://doi.org/10.1371/journal.pmed.0020124 Luo, Y., Liu, J., Zeng, J., & Pan, H. (2024). Global burden of cardiovascular diseases attributed to low physical activity. American journal of preventive cardiology, 17, 100633. https://doi.org/10.1016/j.ajpc.2024.100633 Ye, Z., Det al. (2025). Association of statins use and genetic susceptibility with incidence of Alzheimer's disease. The journal of prevention of Alzheimer's disease, 12(2), 100025. https://doi.org/10.1016/j.tjpad.2024.100025