Is testosterone linked to high blood pressure—or is that a dangerous medical myth? In this episode of Your Infinite Health, we unpack the science behind testosterone replacement therapy (TRT), hormone optimization, and the real cardiovascular risks clinicians are seeing in practice today. Using a powerful real-world patient case involving hypoxic brain injury, exosome therapy, and ADHD stimulant medication, this episode exposes where most people—and even some doctors—are getting it wrong.

Our discussion centers on a young adult patient recovering from a severe methamphetamine overdose that caused anoxic brain injury. After a year of regenerative medicine, hormone optimization, and biologic therapies, his recovery has been remarkable. But when Adderall was reintroduced for ADHD management, his blood pressure spiked, raising urgent questions about whether testosterone therapy causes hypertension.

We dive into the most important clinical research, including a major New England Journal of Medicine trial of over 5,000 men, which found only a 0.3 mmHg increase in blood pressure in men using transdermal testosterone—an amount too small to be clinically significant. Even more importantly, the study showed no increased risk of heart attack or stroke, prompting the FDA to revise cardiovascular warnings on testosterone therapy.

In contrast, we explore the well-documented cardiovascular risks of sympathomimetic stimulant drugs like Adderall and Vyvanse, which are linked to hypertension, accelerated cardiovascular disease, and nervous system overstimulation—especially in patients with neurological trauma or substance abuse history.

You’ll also learn what true “optimization” medicine means: not simply replacing deficient hormones, but maintaining youthful physiologic levels to reduce inflammation, cellular aging, and the accumulation of so-called “zombie cells” that drive chronic disease.

Topics covered in this episode include:
• Testosterone replacement vs optimization
• Testosterone and blood pressure myths
• Adderall, ADHD, and cardiovascular risk
• Sympathetic nervous system overstimulation
• Exosome therapy for brain injury recovery
• Hypogonadism in young adults
• FDA updates on TRT safety
• Regenerative medicine and biologic therapies
• Hormones, aging, inflammation, and longevity

If you’re concerned about TRT safety, high blood pressure, stimulant medications, or longevity-focused medicine, this episode delivers clarity grounded in both clinical data and real patient outcomes.

🎧 Subscribe for more deep dives into hormone health, regenerative medicine, brain recovery, and optimization science.

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Trip Goolsby, MD & LeNae Goolsby are the founders of the Infinite Health Integrative Medicine Center, which provides bio-individualized, peer-reviewed, evidence-based approaches to health optimization, age reversal, and regenerative medicine.

They are also the Authors of the book “Think and Live Longer”. They specialize in helping people across the nation optimize their health and age in reverse, naturally.