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When you hear the words Alzheimer's disease, what do you think of? The truth is, the picture most of us have of the disease is incomplete. Alzheimer's disease doesn't start when someone starts to lose their memory. It actually starts years – sometimes decades – earlier. The Rethinking Alzheimer's Disease Podcast is an engaging, narrative-style podcast miniseries for those curious or motivated to learn about Alzheimer’s disease. Perhaps you have a family member with Alzheimer’s disease, or ca ...
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I'm joined today by Edmarie Guzman-Velez & Rudy Tanzi as we dig into a clinical trial of nicotinamide riboside for Long Covid, why NAD matters for cellular energy, and where the results show promise for fatigue, sleep, mood, and executive function. We share what worked, what did not, and the next steps.
• Overview of NAD, mitochondria, and energy in brain and immune cells
• Why Covid may deplete NAD and how NR restores it
• Trial design using intra-individual crossover with placebo run-in
• Dosing at 2,000 mg NR daily under IRB oversight
• Serial NAD blood measurements confirming a threefold rise
• Outcomes on fatigue, sleep quality, depressive symptoms, executive function
• Limits of small samples and reinfection attrition
• Safety, label guidance, and medical supervision for supplements
• Plans for biomarkers of inflammation and activity data from wearables
• Future research on symptom clusters, sex differences, and combinations
Links:
Full paper available HERE
Dr. Tanzi is paid consultant for, and equity holder in Niagen Biosciences.
Message the podcast! - questions will be answered on my youtube channel :)
For more information about Long Covid Breathing courses & workshops, please check out LongCovidBreathing.com
(music credit - Brock Hewitt, Rule of Life)
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The Long Covid Podcast is self-produced & self funded. If you enjoy what you hear and are able to, please Buy me a coffee or purchase a mug to help cover costs
Transcripts available on individual episodes here
www.LongCovidPodcast.com
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**Disclaimer - you should not rely on any medical information contained in this Podcast and related materials in making medical, health-related or other decisions. Please consult a doctor or other health professional**
Chapters
1. 196 - Cellular Recharge: Can Nicotinamide Riboside help in Long Covid Recovery? (00:00:00)
2. Meet The Guests And Study Aim (00:01:51)
3. Why NAD Matters For Energy And Brain (00:04:08)
4. How COVID May Deplete NAD (00:10:11)
5. Why Nicotinamide Riboside Instead Of NMN (00:11:55)
6. Trial Design And Dosing Choices (00:17:19)
7. Measuring Outcomes And Biomarkers (00:23:50)
8. Results: NAD Up, Symptoms Shift (00:26:27)
9. Executive Function, Fatigue, Sleep, Mood (00:31:18)
10. Safety, Dosage, And Practical Use (00:36:11)
11. Ageing, Inflammation, And Microglia (00:41:36)
12. Next Studies And Biomarker Plans (00:47:46)
13. Reflections, Teamwork, And What’s Next (00:53:48)
198 episodes
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